The use of gonadotrophin-releasing hormone (GnRH) agonist in anaemic subjects awaiting surgery - abstract
WEST INDIAN MED. J
; 46(Suppl 2): 30, Apr. 1997.
Article
en En
| MedCarib
| ID: med-2290
Biblioteca responsable:
JM3.1
Ubicación: JM3.1; R18.W4
ABSTRACT
Gonadotrophin releasing hormone agonist (Goserelin) was used to induce amenorrhea in 27 women who were anaemic as a result of menorrhage due to uterine myomas (fibroids). The aim was to produce a three-month period of amenorrhoea which would be enough time for them to recover from the anaemic status and thus be fit for surgery. GnRH agonists supresses gonadotrophin release from the pituitary, thus inhibiting ovarian steroid secretion, resulting in amenorrhoea. Between March 1993 and May 1996, 27 women were injected with goserelin acetate (zoladex), 3.6 mg in the subcutaneous tissue of the anterior abdominal wall on a monthly basis for 3 months. Twenty three went on to have myomectomy. Haemoglobin (Hb) concentration and packed cell volume (PCV) were determined before initiation of treatment. Haemoglobin levels ranged from 4.7 g/dlto 9.9 g/dl and PCV ranged from 0.14 to 0.30 l/l. Three women did not have amenorrhea after the first injection and reported heavier periods, while three had prolonged light bleeding. All six, plus the other seventeen, had amenorrhoea after the second injection. All experienced hot flushed during the course of treatment and 5 (21.7 percent) had vaginal dryness by the third injection. Demineralization of done which is associated with these agents was not assessed. (Au)
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Colección:
01-internacional
Base de datos:
MedCarib
Asunto principal:
Hormona Liberadora de Gonadotropina
/
Amenorrea
/
Menorragia
Límite:
Female
/
Humans
Idioma:
En
Revista:
WEST INDIAN MED. J
Año:
1997
Tipo del documento:
Article
/
Congress and conference