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Molecular epidemiology of multidrug resistant extended spectrum beta-lactamase producing Klebsiella pneumoniae at a Jamaican hospital, 2000 - 2004
Christian, Nicole A. ; Roye-Green, Karen ; Smikle, Monica.
Afiliación
  • Christian, Nicole A. ; Department of Microbiology. The University of the West Indies. Kingston. Jamaica
  • Roye-Green, Karen ; Department of Microbiology. The University of the West Indeies. Kingston. Jamaica
  • Smikle, Monica; Department of Microbiology. The University of the West Indies. Kingston. Jamaica
BMC microbiol ; BMC microbiol;10(27): [1-8], January 28, 2010. ilus, tab
Article en En | MedCarib | ID: med-17507
Biblioteca responsable: TT5
ABSTRACT

BACKGROUND:

The accurate identification of a pathogen beyond the species level is critical in epidemiological studies and investigations of nosocomial outbreaks of infection. The clonal relatedness of 66 multidrug resistant (MDR) strains of extended spectrum beta-lactamase (ESBL) producing K. pneumoniae isolated from clinical specimens from hospitalized patients at a Jamaican hospital during a 5 year period were determined by pulsed field gel electrophoresis (PFGE).

RESULTS:

A total 10 different ESBL producing K. pneumoniae genotypes designated Clones I-X were found. The most frequently occurring strains belonged to Clones I (21/66, 32%), II (15/66, 26%), III (13/66, 20%) and IV (8/66, 12%) which accounted for 86% (57/66) of ESBL producing K. pneumoniae strains over the 5 year period. The remaining 9 (14%) cases of ESBL producing K. pneumoniae were due to strains of Clones V-X. The 4 predominant clones persisted for several years in the hospital.

CONCLUSIONS:

The clonal and temporal distribution of the MDR ESBL producing K. pneumoniae strains among clinical service areas did not suggest outbreaks of the organism during the period of study. Instead the molecular epidemiology of ESBL producing K. pneumoniae at this hospital was more representative of an endemic persistence of clones of the organism with limited dissemination from patient to patient. Further studies to investigate the factors which determine the emergence and persistence of MDR ESBL producing K. pneumoniae in Jamaican hospitals and their impact on clinical and economic outcomes at such institutions would be useful.
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Texto completo: 1 Colección: 01-internacional Base de datos: MedCarib Asunto principal: Resistencia a Medicamentos / Epidemiología Molecular / Jamaica / Klebsiella pneumoniae Tipo de estudio: Prognostic_studies / Screening_studies Límite: Humans País/Región como asunto: Caribe ingles / Jamaica Idioma: En Revista: BMC microbiol Tipo del documento: Article
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google
Texto completo: 1 Colección: 01-internacional Base de datos: MedCarib Asunto principal: Resistencia a Medicamentos / Epidemiología Molecular / Jamaica / Klebsiella pneumoniae Tipo de estudio: Prognostic_studies / Screening_studies Límite: Humans País/Región como asunto: Caribe ingles / Jamaica Idioma: En Revista: BMC microbiol Tipo del documento: Article