Mother-to-child transmission of human T-cell lymphotropic virus type I associated with prolonged breast-feeding

Witkor, S. Z; Pate, Ernest J; Rosenburg, P. S; Barnett, M; Palmer, P; Medeiros, D; Maloney, Elizabeth M; Blattner, William A

Witkor, S. Z; Pate, Ernest J; Rosenburg, P. S; Barnett, M; Palmer, P; Medeiros, D; Maloney, Elizabeth M; Blattner, William A.

Afiliación

Witkor, S. Z; National Cancer Institute. Viral Epidemiology Branch
Maloney, Elizabeth M; National Cancer Institute. Viral Epidemiology Branch
Blattner, William A; National Cancer Institute, Bethesda, MD, USA. Viral Epidemiology Branch

J Hum Virol ; 1(1): 37-44, Nov.-Dec. 1997.

Article en En | MedCarib | ID: med-1396

Biblioteca responsable: JM3.1

Ubicación: JM3.1;

ABSTRACT

ABSTRACT

OBJECTIVES:

We assessed the risk of transmitting human T-cell lymphotropic virus type I (HTLV-I) through breastfeeding. STUDY DESIGN/

METHODS:

To assess the risk of mother-to-child transmission of HTLV-I, 212 HTLV-I-seropositive women and 145 HTLV-I-seronegative women were enrolled in a prospective cohort study conducted in Kingston, Jamaica. Their offspring were examined at regular intervals, and HTLV-I serostatus was determined at each visit.

RESULTS:

Twenty-eight of the 181 children with at least one postnatal visit born to HTLV-I-seropositive women and (none of the children born to HTLV-I-seronegative women) were persistently seropositive, compared with only 8 (9 percent) of 86 children breast-fed for less than 12 months (relative risk, 3.4; 95 percent CI, 1.7 - 6.9). Compared with children weaned at younger ages, transmission of HTLV-I was associated with continued breast-feeding of children who were 12 to 18 months of age (relative hazard, 6.4; 95 percent CI. 2.1 - 180.2) and older than 18 months (relative hazard, 18.1; 95 percent, 1.4 - 29.5). Transmission was also associated with higher maternal antibody titer (a possible marker of virus load), prolonged duration of ruptured membranes during childbirth, and lower maternal income.

CONCLUSIONS:

These results suggest that limiting the duration of breast-feeding to less than 12 months for children born to HTLV-I-seropositive mothers may significantly reduce mother-to-child transmission of HTLV-I.(Au)

Asunto(s)

Adulto; Femenino; Humanos; Recién Nacido; Lactancia Materna/efectos adversos; Transmisión Vertical de Enfermedad Infecciosa; Infecciones por HTLV-I/transmisión; Virus Linfotrópico T Tipo 1 Humano/inmunología; Infecciones por HTLV-I/inmunología; Infecciones por HTLV-I/virología; Estudios de Cohortes; Estudios Prospectivos

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Colección: 01-internacional Base de datos: MedCarib Asunto principal: Lactancia Materna / Infecciones por HTLV-I / Transmisión Vertical de Enfermedad Infecciosa Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Newborn Idioma: En Revista: J Hum Virol Año: 1997 Tipo del documento: Article

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