Age-related changes on glucose transport and utilization of human erythrocytes: effect of oxidative stress.
Gerontology
; 45(2): 79-82, 1999.
Article
en En
| MEDLINE
| ID: mdl-9933729
BACKGROUND: Normal aging is associated with an impairment in glucose homeostasis. METHODS: In order to investigate the effect of aging on glucose transport and utilization in erythrocytes, the transport and utilization of glucose were measured in erythrocytes from 10 young (mean age 26 +/- 3 years) and 10 elderly (mean age 70 +/- 7 years) healthy individuals. In addition, the glucose transport and utilization were also measured in the presence of cumene hydroperoxide (CumOOH), a toxic organic hydroperoxide that is known to induce oxidative stress. RESULTS: The levels of glucose transport and utilization were significantly lower in the elderly group than the young group (p < 0.05). The glucose transport and utilization were not altered by CumOOH treatment in either young or elderly individuals. CONCLUSION: These results indicate an age-related decrease in the both glucose transport and utilization in erythrocytes.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Derivados del Benceno
/
Envejecimiento
/
Eritrocitos
/
Glucosa
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Gerontology
Año:
1999
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Suiza