Antizyme prevents ornithine decarboxylase-mediated cell death in human fibroblasts.

Tewari, M; Hamid, Q A; Tuncay, O C; Tewari, D S

Tewari, M; Hamid, Q A; Tuncay, O C; Tewari, D S.

Afiliación

Tewari M; Department of Orthodontics and Periodontology, School of Dentistry, Temple University, Philadelphia, PA 19140, USA. mtewari@hal.dental.temple.edu

Oral Oncol ; 34(6): 538-42, 1998 Nov.

Article en En | MEDLINE | ID: mdl-9930368

RESUMEN

Ornithine decarboxylase (ODC) is a key enzyme of polyamine biosynthesis essential for growth-related cellular functions. Apart from its physiological role in cell proliferation, ODC also contributes to the induction of apoptosis under certain conditions, e.g. following growth factor withdrawal. The rate of cell death is a function of its enzyme activity, ODC activity is inhibited by a regulatory protein antizyme, also known to suppress polyamine uptake. We report that forced expression of antizyme prevents ODC-mediated cell death in human gingival fibroblasts under very low serum conditions. These data suggest an important antiapoptotic role for antizyme in cell survival.

Asunto(s)

Apoptosis; Inhibidores de la Ornitina Descarboxilasa; Proteínas/metabolismo; Apoptosis/fisiología; Fibroblastos/enzimología; Encía/citología; Humanos; Ornitina Descarboxilasa/fisiología; Transfección/métodos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas / Apoptosis / Inhibidores de la Ornitina Descarboxilasa Límite: Humans Idioma: En Revista: Oral Oncol Asunto de la revista: NEOPLASIAS Año: 1998 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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