Cross-talk between gammadelta T lymphocytes and immune cells in humoral response.
Immunology
; 95(4): 612-7, 1998 Dec.
Article
en En
| MEDLINE
| ID: mdl-9893053
The role of gamma delta T cells in immunoregulation is largely unknown. In the current study we noted that gamma delta T cells play a positive role in the humoral response. These positively acting gamma delta T cells are required for the successful adoptive cell transfer of the humoral response, as well as for in vitro generation of plaque-forming cells (PFC). The presented results show that gammadelta T cells cause an increase in interleukin-10 (IL-10) production, which partly elucidates the mechanism of action of these cells. However, experiments with cell culture inserts strongly suggest that direct cell-cell contact between immune and gamma delta H-2-compatible regulatory T cells is critical to the exertion of the positive immunoregulatory function of gamma delta cells. The mechanism of cross-talk between these two cell populations is still not clear but we regard as most likely that the positively acting gamma delta T cells may interact with a complex of heat-shock protein-non-polymorphic MHC (IB) on the surface of T helper type 2 and/or B cells. This could provide, by direct cell-cell contact, the cognate recognition between gamma delta T-cell receptors and heat-shock protein-MHC that leads to positive internal signalling in the immune cells.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos B
/
Linfocitos T
/
Receptores de Antígenos de Linfocitos T gamma-delta
/
Interleucina-10
/
Receptor Cross-Talk
/
Formación de Anticuerpos
Límite:
Animals
Idioma:
En
Revista:
Immunology
Año:
1998
Tipo del documento:
Article
País de afiliación:
Polonia
Pais de publicación:
Reino Unido