Diminishing returns from mutation supply rate in asexual populations.

Arjan, J A; Visser, M; Zeyl, C W; Gerrish, P J; Blanchard, J L; Lenski, R E

Arjan, J A; Visser, M; Zeyl, C W; Gerrish, P J; Blanchard, J L; Lenski, R E.

Afiliación

Arjan JA; Center for Microbial Ecology, Michigan State University, East Lansing, MI 48824, USA. arjan.devisser@algemeen.micr.wau.nl

Science ; 283(5400): 404-6, 1999 Jan 15.

Article en En | MEDLINE | ID: mdl-9888858

RESUMEN

Mutator genotypes with increased mutation rates may be especially important in microbial evolution if genetic adaptation is generally limited by the supply of mutations. In experimental populations of the bacterium Escherichia coli, the rate of evolutionary adaptation was proportional to the mutation supply rate only in particular circumstances of small or initially well-adapted populations. These experiments also demonstrate a "speed limit" on adaptive evolution in asexual populations, one that is independent of the mutation supply rate.

Asunto(s)

Evolución Biológica; Escherichia coli/genética; Modelos Biológicos; Mutación; Adaptación Fisiológica; Escherichia coli/fisiología; Genética de Población; Genotipo; Modelos Lineales

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Escherichia coli / Evolución Biológica / Modelos Biológicos / Mutación Idioma: En Revista: Science Año: 1999 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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