The effect of cyclosporin A on cultured rabbit subconjunctival fibroblast proliferation.
Ophthalmologica
; 213(2): 114-9, 1999.
Article
en En
| MEDLINE
| ID: mdl-9885388
The aim of this study was to examine the possible effects of local application of a potent immunosuppressive drug, cyclosporin A (CsA), on fibroblast proliferation in vitro. Rabbit subconjunctival fibroblasts were cultured and incubated with varying doses of CsA (from 0.5 to 5%). Growth inhibition curves were obtained, and cell attachment and reversibility of drug-induced growth inhibition were studied. None of the doses stimulated fibroblast proliferation. CsA inhibited fibroblast proliferation depending on the dose and duration of application. Also, drug-induced growth inhibition decreased depending on dose and duration of application. While the dosage which led to 50% inhibition was found to be 7.2 mg/ml, 4% and higher doses had toxic effects.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ciclosporina
/
Conjuntiva
/
Fibroblastos
/
Inmunosupresores
Límite:
Animals
Idioma:
En
Revista:
Ophthalmologica
Año:
1999
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Suiza