Interactions between lonidamine and beta- or hydroxypropyl-beta-cyclodextrin.

Palmieri, G F; Wehrlé, P; Martelli, S

Palmieri, G F; Wehrlé, P; Martelli, S.

Afiliación

Palmieri GF; Dipartimento di Scienze Chimiche, Università di Camerino, Italy.

Drug Dev Ind Pharm ; 24(7): 653-60, 1998 Jul.

Article en En | MEDLINE | ID: mdl-9876510

RESUMEN

The possibility of obtaining inclusion complexes between lonidamine and beta- or hydroxypropyl-beta-cyclodextrin have been evaluated by phase solubility diagram, differential scanning calorimetry (DSC), and x-ray diffractometry. The applied complexation methods were spray-drying, kneading, and solid dispersion. DSC and x-ray analyses of the powders revealed an external interaction between lonidamine and cyclodextrins. Dissolution profiles of the obtained powders were also studied to define the most appropriate preparation method and molar ratio to use in attempts to increase lonidamine water solubility.

Asunto(s)

Antineoplásicos/química; Ciclodextrinas/química; Indazoles/química; beta-Ciclodextrinas; 2-Hidroxipropil-beta-Ciclodextrina; Rastreo Diferencial de Calorimetría; Interacciones Farmacológicas; Solubilidad; Agua/química; Difracción de Rayos X

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ciclodextrinas / Beta-Ciclodextrinas / Indazoles / Antineoplásicos Idioma: En Revista: Drug Dev Ind Pharm Año: 1998 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido

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