Developmental gene expression and immunohistochemical study of the human endocrine pancreas during fetal life.
Horm Res
; 50(5): 258-63, 1998.
Article
en En
| MEDLINE
| ID: mdl-9873193
The development of human endocrine pancreas has been the subject of many immunohistochemical studies but very little is known at the molecular level. We have determined the patterns of gene expression of glucagon, somatostatin and pancreatic polypeptide during fetal life (16-41 weeks of gestation) using the dot-blot hybridization method. In spite of some dispersion in the mRNA levels, no progressive increase or decrease during this period of fetal life could be found, as previously observed for insulin. In keeping with these molecular data, no increase in immunostaining of the four hormones was observed, but a dispersion of endocrine cells within the exocrine tissue was noticed at 20 weeks of gestation followed by a clear differentiation of the Langerhans islets at 31 weeks. Interestingly, the mRNA levels of the four hormones were always higher in the fetal pancreas than in the adult pancreas.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Islotes Pancreáticos
/
Regulación del Desarrollo de la Expresión Génica
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Horm Res
Año:
1998
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Suiza