Vaginal misoprostol compared with vaginal gemeprost in termination of second trimester pregnancy. A randomized trial.
Contraception
; 58(4): 207-10, 1998 Oct.
Article
en En
| MEDLINE
| ID: mdl-9866000
ABSTRACT
PIP: The efficacies of vaginal gemeprost and vaginal misoprostol for the termination of second-trimester pregnancies were compared in a prospective, randomized trial conducted in Hong Kong, China. 140 women 16-40 years of age requesting pregnancy termination at gestational ages of 14-20 weeks were allocated to receive either 1 mg of gemeprost every 3 hours up to 5 doses (n = 70) or 400 mcg of misoprostol every 3 hours up to 5 doses (n = 70). 56 women (80.0%) in the misoprostol group and 41 (58.6%) in the gemeprost group aborted within 24 hours. In primigravidas, the rate of successful abortion was significantly higher in the misoprostol group (83.3%) than the gemeprost group (55.3%). There were no significant between-group differences in this rate for multigravid women. The median induction-abortion interval was significantly shorter in the misoprostol group (14.1 hours) than the gemeprost group (19.5 hours). Blood loss during the procedure was similar in both groups. Although there was no significant difference in the incidence of side effects, diarrhea was less common in misoprostol acceptors (24.3%) than in women who received gemeprost (40.0%). In addition to being more effective at inducing abortion, misoprostol is substantially less expensive than gemeprost and does not require refrigerated transport and storage facilities. Thus, misoprostol, with or without mifepristone, should be the drug of choice for termination of mid-trimester pregnancies. Further studies are needed, however, to determine the optimal dose and frequency of administration.
Palabras clave
Abortifacient Agents; Abortion, Drug Induced; Abortion, Induced; Asia; Biology; Comparative Studies; Developing Countries; Eastern Asia; Endocrine System; Family Planning; Fertility Control, Postconception; Hong Kong; Misoprostol--administraction and dosage; Physiology; Prostaglandins; Prostaglandins, Synthetic; Research Methodology; Research Report; Studies
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Abortivos no Esteroideos
/
Alprostadil
/
Misoprostol
/
Aborto Inducido
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Contraception
Año:
1998
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Estados Unidos