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Physiological and pathophysiological regulation of cytochrome P450.
Morgan, E T; Sewer, M B; Iber, H; Gonzalez, F J; Lee, Y H; Tukey, R H; Okino, S; Vu, T; Chen, Y H; Sidhu, J S; Omiecinski, C J.
Afiliación
  • Morgan ET; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA. etmorga@emory.edu
Drug Metab Dispos ; 26(12): 1232-40, 1998 Dec.
Article en En | MEDLINE | ID: mdl-9860933
This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the April 1998 Experimental Biology '98 meeting in San Francisco. The presentations focused on the mechanisms of regulation of cytochrome P450 gene expression by developmental factors and by hormones and cytokines, as well as on the interplay between physiological and chemical regulation. Approaches and systems used to address these questions included conditional gene knockouts in mice, primary hepatocyte cultures, immunofluorescence imaging of cells, and cell lines stably expressing reporter gene constructs.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación Enzimológica de la Expresión Génica / Sistema Enzimático del Citocromo P-450 Límite: Animals / Humans Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 1998 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación Enzimológica de la Expresión Génica / Sistema Enzimático del Citocromo P-450 Límite: Animals / Humans Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 1998 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos