[Causes and risks of hyperlipidemia during dialysis and after renal transplantation]. / Cause e rischi dell'iperlipidemia durante trattamento dialitico e dopo trapianto renale.
Recenti Prog Med
; 89(11): 590-7, 1998 Nov.
Article
en It
| MEDLINE
| ID: mdl-9844447
The most widely studied hyperlipidemies in patients affected by renal insufficiency or subsequent to kidney transplant present phenotype IIa, IIb or IV. The lipidic alteration most frequently observed in chronic renal insufficiency and/or dialytic treatment is represented by hypertrigliceridemia as a result of: 1) altered VLDL metabolism; 2) reduced activity of lecithin cholesterol acyltransferase (LCAT); 3) decrease in Apo-A1 and HDL3. Furthermore, marked anomalies in lipoprotein Lp (a) have been reported in hemodialysis. In patients undergoing peritoneal dialysis, hyperlipidemia arises from both an anomalous retrograde absorption of glucose and protein dispersion. Following kidney transplant the most frequent hyperlipidemia is hypercholesterolemia, consequent to immunosuppressive treatment (mainly steroids and cyclosporin). The documented significant increase of cardiovascular risk in the presence of hyperlipidemia points to the need for a clearer etiopathogenic definition of this anomaly, as well as the necessity to find an efficacious pharmacological treatment.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Diálisis Renal
/
Trasplante de Riñón
/
Hiperlipidemias
/
Fallo Renal Crónico
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
It
Revista:
Recenti Prog Med
Año:
1998
Tipo del documento:
Article
Pais de publicación:
Italia