Factors influencing the induction of infertility in a mouse model of Chlamydia trachomatis ascending genital tract infection.
J Med Microbiol
; 47(7): 599-605, 1998 Jul.
Article
en En
| MEDLINE
| ID: mdl-9839564
In women, infections due to Chlamydia trachomatis frequently result in long-term sequelae including chronic abdominal pain, ectopic pregnancy and infertility. In an attempt to characterise the pathogenesis of the infection, female C3H (H-2k) mice were inoculated intravaginally with different doses of C. trachomatis and then mated with proven male breeder mice. The inoculated mice developed a broad spectrum of clinical manifestations ranging from infertility to asymptomatic shedding. The dose inducing infertility in 50% of the mice was c. 10(5) inclusion-forming units of C. trachomatis. In another group of mice sampled at intervals after intravaginal inoculation, C. trachomatis was recovered from the upper genital tract starting at 24 h after infection. A higher percentage of animals infected during the luteal phase of the oestrous cycle had positive cultures from the middle and upper genital tract than when mice were inoculated during the follicular phase. These results indicate that rapid therapeutic intervention is required to avoid the sequelae resulting from C. trachomatis genital infection, and suggest that hormonal factors play a role in the pathogenesis of the disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por Chlamydia
/
Chlamydia trachomatis
/
Enfermedades de los Genitales Femeninos
/
Infertilidad Femenina
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Med Microbiol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido