Tests of toxicity and teratogenicity in biphasic vertebrates treated with heavy metals (Cr3+, Al3+, Cd2+).

Calevro, F; Campani, S; Ragghianti, M; Bucci, S; Mancino, G

Calevro, F; Campani, S; Ragghianti, M; Bucci, S; Mancino, G.

Afiliación

Calevro F; Dipartimento di Fisiologia e Biochimica, Università di Pisa, Ghezzano (PI), Italy.

Chemosphere ; 37(14-15): 3011-7, 1998 Dec.

Article en En | MEDLINE | ID: mdl-9839411

RESUMEN

Developmental toxicity of chromium(III), aluminium(III) and cadmium(II) were evaluated by examining abnormalities and mortality in embryos belonging to different species of amphibians. Cr(III) and Al(III) are lethal at 1.5 mM concentration, and seriously affect the differentiation of central nervous system, skeleton and eye, and cause cephalic and trunk oedemas at lower concentrations, being aluminium significantly more harmful than chromium. Cd(II), tested only in P. waltl, is highly toxic: embryos exposed to concentrations ranging from 0.18 to 50 microM display malformations, delay and arrest of development in a dose dependent manner.

Asunto(s)

Aluminio/toxicidad; Cadmio/toxicidad; Cromo/toxicidad; Mutágenos/toxicidad; Óvulo/efectos de los fármacos; Pruebas de Toxicidad; Animales; Monitoreo del Ambiente/métodos; Pleurodeles; Rana esculenta; Salamandridae; Especificidad de la Especie

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óvulo / Cadmio / Cromo / Pruebas de Toxicidad / Aluminio / Mutágenos Límite: Animals Idioma: En Revista: Chemosphere Año: 1998 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido

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