[Evaluation of the inhaled glucocorticosteroid effects on non specific bronchial reactivity with particular reference to the late inflammatory phase in atopic asthma patients. II. The effect of regular administration of budesonide R on specific and non-specific bronchial reactivity]. / Wplyw wziewnych glikokortykosteroidów na nieswoista i poalergenowa reaktywnosc oskrzeli ze szczególnym uwzglednieniem póznej fazy zapalnej u chorych na atopowa astme oskrzelowa. II. Wplyw regularnego stosowania budezonidu R na odczyn zapalny oraz swoista i nieswoista reaktywnosc oskrzeli.
Pol Merkur Lekarski
; 4(23): 250-3, 1998 May.
Article
en Pl
| MEDLINE
| ID: mdl-9825654
The purpose of the study was to determine whether regular administration of budesonide R decreases inflammation, specific and non-specific bronchial hyperreactivity in allergic asthma patients. The studies were carried out on 16 patients suffering from mild to moderate allergic asthma, sensitive to D. pteronyssinus allergen. After performance of the specific and non-specific bronchial provocation tests, collection of blood samples for an ECP evaluation, the patients were regularly treated with budesonide R, 2 x 320 micrograms for a period of 8 weeks. At the end of the study the BPTs and blood collection were repeated. BPTs with methacholine and D. pteronyssinus were performed according to Ryan's method. After the allergen challenge, early (EAR) and late asthmatic reaction (LAR) were to be observed. After the therapy non-specific BHR to methacholine expressed as PC20FEV1 and specific BHR to allergen (PD20FEV1D. pteronyssinus) and serum ECP concentrations decreased significantly. Although after the treatment with budesonide R, the patients had to inhale much larger amounts of allergen, in order to induce EAR, the number of LAR did not change significantly. After treatment the LAR appeared about 1 hour later and the decrease in FEV1 was less than previously. We conclude that budesonide R decreases the intensity of the inflammation and BHR.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Respiración
/
Asma
/
Bronquios
/
Budesonida
/
Dermatitis Atópica
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
Pl
Revista:
Pol Merkur Lekarski
Asunto de la revista:
MEDICINA
Año:
1998
Tipo del documento:
Article
Pais de publicación:
Polonia