Effects of Ginkgo biloba extract on the cochlear damage induced by local gentamicin installation in guinea pigs.
J Korean Med Sci
; 13(5): 525-8, 1998 Oct.
Article
en En
| MEDLINE
| ID: mdl-9811183
Investigations evaluating the protective effect of Ginkgo biloba extract (EGb) on gentamicin (GM) ototoxicity were undertaken. Guinea pigs treated with 5 mg/kg gentamicin sulfate on the round window niche (RWN) showed acute changes on electrocochleogram and hair cell or microvilli damage on scanning electron microscopy (SEM). There was accumulation of GM in the whole cochlea, especially in the organ of Corti, stria vascularis, and type III fibrocyte on immunohistochemical study. However, the guinea pigs pretreated with local or systemic EGb revealed no significant changes by local GM installation. From these results, we concluded that EGb has a protective effect on the development of GM ototoxicity in the cochlea.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plantas Medicinales
/
Gentamicinas
/
Cóclea
/
Ginkgo biloba
/
Fitoterapia
Límite:
Animals
Idioma:
En
Revista:
J Korean Med Sci
Asunto de la revista:
MEDICINA
Año:
1998
Tipo del documento:
Article
Pais de publicación:
Corea del Sur