Comparison of AIK-C measles vaccine in infants at 6 months with Schwarz vaccine at 9 months: a randomized controlled trial in Ghana.
Bull World Health Organ
; 76(4): 353-9, 1998.
Article
en En
| MEDLINE
| ID: mdl-9803586
ABSTRACT
PIP: The seroresponse of standard-dose heat-stable AIK-C measles vaccine administered to infants at 6 months of age was compared to that of standard-dose Schwarz vaccine administered at 9 months of age in a measles-endemic area in West Africa. The study was conducted in Asamankese, the capital town of Ghana's East Akim District. Infants 24-27 weeks of age who had been attending the Asamankese maternal-child health clinic regularly and had received all the required immunizations were enrolled and randomly assigned to receive the AIK-C (n = 184) or the Schwarz (n = 193) vaccine. No severe adverse reactions were reported during the 10-day follow-up period in either vaccine group. In the AIK-C group, 96.9% of infants who were seronegative at preimmunization and 79.4% of those with preexisting antibodies had seroconverted by 3 months after immunization; at 6 months after immunization, these rates were 97.3% and 100%, respectively. In the Schwarz group, 98.2% of infants seronegative at immunization and 100% of those with preexisting antibodies seroconverted by 3 months after immunization; at 6 months, these rates were 99.1% and 80%, respectively. Although the geometric mean titres achieved were significantly higher in the Schwarz vaccine group, these titres were above the protective level of 200 mIU in the AIK-C group. Administration of measles vaccine at a younger age may be more easily incorporated into current Expanded Program on Immunization schedules.
Palabras clave
Africa; Africa South Of The Sahara; Age Factors; Child Health Services; Comparative Studies; Delivery Of Health Care; Demographic Factors; Developing Countries; Diseases; English Speaking Africa; Ghana; Health; Health Services; Immunization; Infant; Maternal-child Health Services; Measles--prevention and control; Population; Population Characteristics; Primary Health Care; Research Methodology; Research Report; Studies; Vaccination; Vaccines--administraction and dosage; Viral Diseases; Western Africa; Youth
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vacuna Antisarampión
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Enfermedades Endémicas
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Sarampión
Tipo de estudio:
Clinical_trials
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Diagnostic_studies
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Evaluation_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Female
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Humans
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Infant
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Male
País/Región como asunto:
Africa
Idioma:
En
Revista:
Bull World Health Organ
Año:
1998
Tipo del documento:
Article
País de afiliación:
Ghana
Pais de publicación:
Suiza