Levels of circulating nitrate/nitrite and gamma interferon not increased in uncomplicated malaria.

Torre, D; Ferrario, G; Matteelli, A; Speranza, F; Giola, M; Pugliese, A; Cantamessa, C; Carosi, G; Fiori, G P

Torre, D; Ferrario, G; Matteelli, A; Speranza, F; Giola, M; Pugliese, A; Cantamessa, C; Carosi, G; Fiori, G P.

Afiliación

Torre D; Div. of Infectious Diseases, Regional Hospital, Varese, Italy.

Infection ; 26(5): 301-3, 1998.

Article en En | MEDLINE | ID: mdl-9795789

RESUMEN

The purpose of this study was to evaluate nitric oxide (NO) activity in patients with uncomplicated malaria. Lipopolysaccharide and gamma interferon (IFN-gamma) are potent inducers of NO by inducing production of NO synthase. NO activity was determined by measuring serum levels of nitrite/nitrate (metabolic end products of NO), and IFN-gamma in patients with uncomplicated malaria, mostly caused by Plasmodium falciparum. Neither serum levels of nitrite/nitrate nor of IFN-gamma were significantly increased in patients with uncomplicated malaria, especially in patients with P. falciparum infection, and in those with high parasitaemia. These results show that NO cannot play a role in uncomplicated malaria, and it is still debatable if NO production in this infection has beneficial or detrimental effects.

Asunto(s)

Interferón gamma/sangre; Malaria/sangre; Nitratos/sangre; Nitritos/sangre; Adulto; Humanos; Malaria/parasitología; Malaria Falciparum/sangre; Persona de Mediana Edad; Óxido Nítrico/sangre

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interferón gamma / Malaria / Nitratos / Nitritos Límite: Adult / Humans / Middle aged Idioma: En Revista: Infection Año: 1998 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania

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