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Synthesis of phosphoramide mustard analogues of daunomycin and carminomycin.
Csorvási, A; Kövér, K E; Menyhárt, M M; Sztaricskai, F; Dobrynin, Y V; Nikolaeva, T G.
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  • Csorvási A; Research Group for Antibiotics of the Hungarian Academy of Sciences, L. Kossuth University, Debrecen, Hungary.
Arch Pharm (Weinheim) ; 331(9): 265-8, 1998 Sep.
Article en En | MEDLINE | ID: mdl-9793480
New phosphoramide mustards (6-8) have been prepared from the antibiotics 2 and 3, and from 5. The mixture of cyclophosphamides could be separated by preparative layer and column chromatography. The assignments of configuration to the isomeric phosphoramidates was based on the magnetic anisotropy of the P = O bond. The synthesized compounds 6a,b-8a,b (mixture of isomers) were tested for inhibitory activity on the [3H]-thymidine incorporation into the DNA of tumor cells, using ovarian carcinoma cell line.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mostazas de Fosforamida / Carubicina / Daunorrubicina / Antineoplásicos Alquilantes Límite: Humans Idioma: En Revista: Arch Pharm (Weinheim) Año: 1998 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Alemania
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mostazas de Fosforamida / Carubicina / Daunorrubicina / Antineoplásicos Alquilantes Límite: Humans Idioma: En Revista: Arch Pharm (Weinheim) Año: 1998 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Alemania