Growth hormone response to placebo, apomorphine and growth hormone releasing hormone in abstinent alcoholics and control subjects.

Wiesbeck, G A; Mueller, T; Wodarz, N; Davids, E; Kraus, T; Thome, J; Weijers, H G; Boening, J

Wiesbeck, G A; Mueller, T; Wodarz, N; Davids, E; Kraus, T; Thome, J; Weijers, H G; Boening, J.

Afiliación

Wiesbeck GA; Department of Psychiatry, University of Wuerzburg, Germany.

Drug Alcohol Depend ; 52(1): 53-6, 1998 Sep 01.

Article en En | MEDLINE | ID: mdl-9788006

RESUMEN

Abstinent alcoholics and control subjects were challenged with placebo (saline), growth hormone releasing hormone (GHRH) and apomorphine (APO). While both groups did not differ in their growth hormone response (HGH) to placebo and GHRH, the alcoholics revealed a significant lower HGH response to dopamine receptor stimulation with APO. These findings provide no evidence that in abstinent alcoholics HGH blunting after dopamine receptor stimulation could be related to an alteration at the pituitary level but they give neuroendocrinological support to the hypothesis of a lower dopamine receptor sensitivity in abstinent alcoholics.

Asunto(s)

Alcoholismo/rehabilitación; Apomorfina/farmacología; Hormona Liberadora de Hormona del Crecimiento/farmacología; Hormona de Crecimiento Humana/farmacología; Receptores Dopaminérgicos/efectos de los fármacos; Adulto; Humanos; Masculino; Hipófisis/efectos de los fármacos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apomorfina / Hormona Liberadora de Hormona del Crecimiento / Receptores Dopaminérgicos / Hormona de Crecimiento Humana / Alcoholismo Tipo de estudio: Clinical_trials Límite: Adult / Humans / Male Idioma: En Revista: Drug Alcohol Depend Año: 1998 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Irlanda

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