Good growth despite very low levels of insulin-like growth factors.
Eur J Pediatr
; 157(9): 712-4, 1998 Sep.
Article
en En
| MEDLINE
| ID: mdl-9776527
UNLABELLED: A 12.5-year-old girl presented with short stature. Insulin-like growth factor 1(IGF-I) and insulin- like growth factor binding protein (IGFBP-3) were below the 0.1 percentile. Growth hormone provocation tests disclosed normal responses to L-arginine and insulin-induced hypoglycaemia. A huge benign mesenteric cyst was discovered by abdominal ultrasound and completely removed. Subsequently, the girl showed a marked catch-up growth; however, IGF-I and IGFBP-3 remained below the 0.1 percentile. CONCLUSION: These observations imply that growth may take place even with very low levels of insulin-like growth factors. The interpretation of low IGF-I and IGFBP-3 levels in short children still requires good clinical judgement and basic knowledge of their biological action.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factor I del Crecimiento Similar a la Insulina
/
Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina
/
Crecimiento
Límite:
Child
/
Female
/
Humans
Idioma:
En
Revista:
Eur J Pediatr
Año:
1998
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Alemania