A randomized cross-over study on various hormonal parameters of two triphasic oral contraceptives.
Contraception
; 58(2): 75-81, 1998 Aug.
Article
en En
| MEDLINE
| ID: mdl-9773261
ABSTRACT
PIP: A randomized crossover study involving 26 women in Germany investigated the effect of two triphasic oral contraceptives (OCs) on selected hormonal parameters. The first triphasic, Trisiston, contained 0.03 mg of ethinyl estradiol (EE) and 0.05 mg of levonorgestrel (LNG) (6 tablets), 0.04 mg EE and 0.075 mg LNG (6 tablets), and 0.03 mg EE and 0.15 mg LNG (9 tablets). The second, Triquilar, differed from the first in the second (5 tablets) and third (10 tablets) phases. Serum samples were collected on days 6, 11, 21, and 28 of the control and washout cycles and the third treatment cycle. There were no significant differences in the hormonal effects of the two formulations. Both triphasics inhibited ovulation reliably and decreased serum levels of gonadotropins, free testosterone, and dehydroepiandrosterone sulfate in a time-dependent manner. Estradiol and testosterone were already suppressed on day 6. Prolactin rose sporadically in some women, but was not significantly changed. In contrast, levels of sex hormone binding globulin, corticosteroid binding globulin, and cortisol were significantly elevated by 100%. During the 7-day hormone-free interval, all parameters returned at least partly to baseline. These findings suggest a direct inhibitory effect of OC steroids on ovarian steroid synthesis.
Palabras clave
Androgens; Biology; Clinical Research; Contraception; Contraceptive Agents, Estrogen--administraction and dosage; Contraceptive Agents, Female--administraction and dosage; Contraceptive Agents, Progestin--administraction and dosage; Contraceptive Agents--administraction and dosage; Contraceptive Methods--pharmacodynamics; Developed Countries; Endocrine System; Ethinyl Estradiol--administraction and dosage; Europe; Family Planning; Genitalia; Genitalia, Female; Germany; Gonadotropins; Hormones; Levonorgestrel--administraction and dosage; Oral Contraceptives, Combined--pharmacodynamics; Oral Contraceptives, Phasic--pharmacodynamics; Oral Contraceptives--pharmacodynamics; Ovarian Effects; Ovary; Physiology; Research Methodology; Research Report; Urogenital System; Western Europe
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pregnenodionas
/
Hormonas Esteroides Gonadales
/
Anticonceptivos Orales Combinados
/
Anticonceptivos Sintéticos Orales
/
Combinación Etinil Estradiol-Norgestrel
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Contraception
Año:
1998
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Estados Unidos