[Hypersensitive urticarial vasculitis after natisedine intake]. / Vasculite urticarienne d'hypersensibilité après prise de Natisédine.
Ann Dermatol Venereol
; 124(6-7): 457-9, 1997.
Article
en Fr
| MEDLINE
| ID: mdl-9739909
BACKGROUND: Various skin and mucosal reactions can be observed after administration of quinidine derivatives. CASE REPORT: A patient who was taking Natisédine (quinidine phenylethyl barbiturate) intermittently and at reintroduction developed a papulopurpuric eruption (without thrombopenia) producing extensive centrifugal annular infiltration and central healing which regressed approximately one week after drug withdrawal. This eruption was associated with moderate 24 h proteinuria. The clinical aspect was that of vasculitis purpura as confirmed histology. Direct immunofluorescence only demonstrated C3 deposits in the vessel walls of the superficial dermis. The quinidine moiety of this drug (currently removed from the formulation) appears to be the responsible agent (imputability score: 13 B3). DISCUSSION: Thrombopenic purpura by synthesis of anti-platelet antibodies induced by quinidine derivatives is well known. Inversely, cases of non-thrombopenic purpura imputable to these same derivatives is uncommon (7 reported cases). The pathophysiological mechanisms involved might be similar (antigenic similarity between the platelet surface and endothelium).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quinidina
/
Urticaria
/
Vasculitis Leucocitoclástica Cutánea
/
Antiarrítmicos
Límite:
Aged
/
Aged80
/
Female
/
Humans
Idioma:
Fr
Revista:
Ann Dermatol Venereol
Año:
1997
Tipo del documento:
Article
Pais de publicación:
Francia