Malignant change in a duodenal adenoma in familial adenomatous polyposis: report of a case.
Am J Gastroenterol
; 93(9): 1566-8, 1998 Sep.
Article
en En
| MEDLINE
| ID: mdl-9732948
Patients with FAP (familial adenomatous polyposis) are known to be at high risk for duodenal cancer. Although the adenoma-carcinoma sequence is thought to exist in the duodenum, clinical observation of the development of duodenal adenoma to cancer has rarely been reported. We outline a 44-yr-old postcolectomy man with FAP who underwent regular gastroduodenoscopy annually or biannually and was found to be harboring duodenal ampullary cancer 5 yr after colectomy. Endoscopic and pathological examination of the ampullary lesion during these 5 yr revealed progression of pathology from adenoma to carcinoma. Pathology of the surgical specimen confirmed ampullary cancer. This in vivo demonstration of the adenoma-carcinoma sequence highlights the current limitations of duodenal surveillance in FAP.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carcinoma
/
Adenoma
/
Poliposis Adenomatosa del Colon
/
Neoplasias Duodenales
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Am J Gastroenterol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Estados Unidos