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Preoperative localization of parathyroid lesions in hyperparathyroidism: relationship between technetium-99m-MIBI uptake and oxyphil cell content.
Carpentier, A; Jeannotte, S; Verreault, J; Lefebvre, B; Bisson, G; Mongeau, C J; Maheux, P.
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  • Carpentier A; Department of Medicine, Faculté de Médecine, Université de Sherbrooke, Québec, Canada.
J Nucl Med ; 39(8): 1441-4, 1998 Aug.
Article en En | MEDLINE | ID: mdl-9708524
UNLABELLED: The aim of this study was to assess the relationship between parathyroid oxyphil cell content and early or late phases of uptake of 99mTc-MIBI, a radioisotope preferentially retained in mitochondria-rich cells. METHODS: This study is a retrospective, single-blind analysis of all double-phase 99mTc-MIBI parathyroid scintigraphy studies performed before surgery in our institution between 1990 and 1995. A total of 18 parathyroid lesions in 14 patients were reviewed. This sample included 11 cases of primary hyperparathyroidism (8 adenomas, 1 adenocarcinoma and 2 hyperplasias) and 3 cases of tertiary hyperparathyroidism secondary to chronic renal failure. RESULTS: Uptake of 99mTc-MIBI in the early phase of scintigraphy was associated with larger parathyroid lesions (1.61 +/- 1.61 ml versus 0.33 +/- 0.27 ml; p < 0.02) and higher serum calcium levels (3.00 +/- 0.41 mM versus 2.67 +/- 0.14 mM; p < 0.02). More importantly, we found that a parathyroid oxyphil cell content greater than 25% was more often associated with a positive uptake of 99mTc-MIBI in the late phase of the test (positive late uptake in 78% of lesions with a high oxyphil cell content versus 33% in lesions with an oxyphil cell content between 1% and 25% and 0% in lesions with no oxyphil cells; p < 0.04). CONCLUSION: These findings suggest that the late retention of 99mTc-MIBI in double-phase scintigraphy is related to parathyroid oxyphil cell content.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de las Paratiroides / Glándulas Paratiroides / Tecnecio Tc 99m Sestamibi / Adenoma Oxifílico / Radiofármacos / Hiperparatiroidismo Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Nucl Med Año: 1998 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de las Paratiroides / Glándulas Paratiroides / Tecnecio Tc 99m Sestamibi / Adenoma Oxifílico / Radiofármacos / Hiperparatiroidismo Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Nucl Med Año: 1998 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos