Oligoclonal expansions of CD8(+) T cells in chronic HIV infection are antigen specific.
J Exp Med
; 188(4): 785-90, 1998 Aug 17.
Article
en En
| MEDLINE
| ID: mdl-9705961
Acute HIV infection is associated with a vigorous immune response characterized by the proliferation of selected T cell receptor V beta (BV)-expressing CD8(+) T cells. These 'expansions', which are commonly detected in the peripheral blood, can persist during chronic HIV infection and may result in the dominance of particular clones. Such clonal populations are most consistent with antigen-driven expansions of CD8(+) T cells. However, due to the difficulties in studying antigen-specific T cells in vivo, it has been hard to prove that oligoclonal BV expansions are actually HIV specific. The use of tetrameric major histocompatibility complex-peptide complexes has recently enabled direct visualization of antigen-specific T cells ex vivo but has not provided information on their clonal composition. We have now made use of these tetrameric complexes in conjunction with anti-BV chain-specific monoclonal antibodies and analysis of cytotoxic T lymphocyte lines/clones to show that chronically clonally expanded CD8(+) T cells are HIV specific in vivo.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por VIH
/
Receptores de Antígenos de Linfocitos T alfa-beta
/
Linfocitos T CD8-positivos
Límite:
Humans
Idioma:
En
Revista:
J Exp Med
Año:
1998
Tipo del documento:
Article
País de afiliación:
Reino Unido
Pais de publicación:
Estados Unidos