Immunohistochemical localization of galectin-3 in malignant and benign human thyroid tissue.
Anticancer Res
; 18(4A): 2637-41, 1998.
Article
en En
| MEDLINE
| ID: mdl-9703921
BACKGROUND: Galectin-3 is an endogenous beta-galactoside binding lectin with putative roles in development, immunomodulation, transformation and metastasis. The purpose of this study was to analyze galectin-3 expression in a series of human thyroid neoplastic lesions. METHODS: A total of 76 cases, including 47 specimens of thyroid malignancies, 14 follicular adenomas and 15 specimens of normal thyroid tissue, were analyzed immunohistochemically using a monoclonal antibody to galectin-3 and avidin-biotin-peroxidase complex (ABC) method. RESULTS: The immunohistochemical staining results showed galectin-3 expression in neoplastic cells of all 20 cases of papillary carcinoma, 11 out of 15 follicular carcinomas, both oxyphilic carcinomas, all 10 anaplastic carcinomas and 5 out of 14 follicular adenomas. Galectin-3 localization was mostly cytoplasmic, but also membraneous or nuclear in some cells. Follicular cells in normal thyroid tissue were negative. CONCLUSIONS: The results of this study indicate that galectin-3 gene is expressed at the protein level in most thyroid carcinomas and some adenomas. Galectin-3 expression was not clearly correlated with histopathological aggressiveness, dedifferentiation state or determination of malignancy of the follicular tumour. The role of galectin-3 in thyroid tumour biology remains to be elucidated.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glándula Tiroides
/
Neoplasias de la Tiroides
/
Antígenos de Diferenciación
/
Adenoma
Límite:
Humans
Idioma:
En
Revista:
Anticancer Res
Año:
1998
Tipo del documento:
Article
País de afiliación:
Yugoslavia
Pais de publicación:
Grecia