Immunoenzymatic determination of atrazine in rat tissue samples.
Toxicology
; 127(1-3): 11-6, 1998 May 15.
Article
en En
| MEDLINE
| ID: mdl-9699789
In the present study our objective was to adapt a competitive enzyme immunoassay (EIA) for the determination of atrazine in animal tissues (liver and kidney). Female Wistar rats were administered through gavage with a single dose of atrazine (500 or 1000 mg/kg body weight) and sacrificed 24, 48 h and 7 days following the exposure. Using liver tissue samples the extraction procedure was improved. The atrazine concentrations measured in the liver were higher than those found in the kidney, but both can be ranked as low compared with the amount of the administered doses. These data confirm that tissue retention is minimal. Further studies are necessary in order to make an overall evaluation concerning the amount of atrazine retained in the organism. We consider that the competitive EIA may be a promising technique for epidemiological screening of pesticides.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Atrazina
/
Residuos de Plaguicidas
/
Herbicidas
/
Riñón
/
Hígado
Límite:
Animals
Idioma:
En
Revista:
Toxicology
Año:
1998
Tipo del documento:
Article
País de afiliación:
Rumanía
Pais de publicación:
Irlanda