N-terminal processing: the methionine aminopeptidase and N alpha-acetyl transferase families.

Bradshaw, R A; Brickey, W W; Walker, K W

Bradshaw, R A; Brickey, W W; Walker, K W.

Afiliación

Bradshaw RA; Dept of Physiology and Biophysics, College of Medicine, University of California, Irvine 92697, USA.

Trends Biochem Sci ; 23(7): 263-7, 1998 Jul.

Article en En | MEDLINE | ID: mdl-9697417

RESUMEN

Removal of the initiator methionine and/or acetylation of the alpha-amino group are among the earliest possible chemical modifications that occur during protein synthesis in eukaryotes. These events are catalyzed by methionine aminopeptidase and N alpha-acetyltransferase, respectively. Recent advances in the isolation and characterization of these enzymes indicate that they exist as isoforms that vary in cellular location, function, and evolutionary origins.

Asunto(s)

Acetiltransferasas/metabolismo; Aminopeptidasas/metabolismo; Acetiltransferasas/química; Acetiltransferasas/genética; Aminopeptidasas/química; Aminopeptidasas/genética; Animales; Evolución Molecular; Humanos; Metionil Aminopeptidasas; Modelos Moleculares; Conformación Proteica; Procesamiento Proteico-Postraduccional

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acetiltransferasas / Aminopeptidasas Límite: Animals / Humans Idioma: En Revista: Trends Biochem Sci Año: 1998 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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