Recent developments in the use of vitamin D analogues.
Curr Opin Nephrol Hypertens
; 7(4): 397-403, 1998 Jul.
Article
en En
| MEDLINE
| ID: mdl-9690038
The activated form of vitamin D3, 1 alpha,25(OH)2D3, not only plays a central role in bone and calcium metabolism, but also has potent antiproliferative and prodifferentiating effects. Moreover, the combined presence of 25(OH)D3-1 alpha-hydroxylase, as well as the vitamin D receptor in several tissues introduced the idea of a paracrine role for 1 alpha,25(OH)2D3. By introducing chemical modifications into the flexible molecule 1 alpha,25(OH)2D3, a whole generation of vitamin D analogues was created. Due to a clear dissociation of the antiproliferative and prodifferentiating effects from calcaemic effects, these analogues can be used not only for the treatment of bone disorders but also for non-classical applications. In the present review, a summary is given on the use of the 1 alpha,25(OH)2D3 analogues for the treatment of psoriasis, cancer and immune disorders together with new insights in the mechanism of action of these analogues.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vitamina D
/
Calcitriol
Límite:
Animals
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Curr Opin Nephrol Hypertens
Asunto de la revista:
ANGIOLOGIA
/
NEFROLOGIA
Año:
1998
Tipo del documento:
Article
País de afiliación:
Bélgica
Pais de publicación:
Reino Unido