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Insulin increases expression of apobec-1, the catalytic subunit of the apolipoprotein B mRNA editing complex in rat hepatocytes.
von Wronski, M A; Hirano, K I; Cagen, L M; Wilcox, H G; Raghow, R; Thorngate, F E; Heimberg, M; Davidson, N O; Elam, M B.
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  • von Wronski MA; Department of Pharmacology, The Health Science Center, University of Tennessee, Memphis 38163, USA.
Metabolism ; 47(7): 869-73, 1998 Jul.
Article en En | MEDLINE | ID: mdl-9667237
We have previously shown that chronic insulin treatment of rat hepatocytes increases the fraction of edited apolipoprotein B (apoB) mRNA from approximately 50% to as much as 90%. We have now examined the effect of insulin on apobec-1 mRNA abundance and demonstrate that increased editing of apoB mRNA following insulin treatment is accompanied by elevated apobec-1 mRNA levels in primary rat hepatocytes. Time-course measurements of the effects of insulin on apoB mRNA editing and apobec-1 mRNA abundance showed that both were elevated almost maximally within 48 hours and sustained for at least 5 days of insulin treatment.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apolipoproteínas B / ARN Mensajero / Edición de ARN / Citidina Desaminasa / Insulina / Hígado Límite: Animals Idioma: En Revista: Metabolism Año: 1998 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Buscar en Google
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Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apolipoproteínas B / ARN Mensajero / Edición de ARN / Citidina Desaminasa / Insulina / Hígado Límite: Animals Idioma: En Revista: Metabolism Año: 1998 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos