[Nerve growth factor and diabetic neuropathy]. / Factor de crecimiento nervioso y neuropatía diabética.
Rev Neurol
; 26(154): 1032-9, 1998 Jun.
Article
en Es
| MEDLINE
| ID: mdl-9658489
INTRODUCTION: The progress made by contemporary neurobiology opens new horizons both for study and for treatment of disorders of the nervous system. At the present time we are in the age of growth factors. These are molecules which affect survival, development and the normal functioning of cell populations. DEVELOPMENT: One of the most widely studied growth factors is nervous growth factor (NGF) which is necessary for normal life of various types of neurones, including sensory nerves and nerves derived from the neural crests. Diabetic neuropathy, worldwide a major neurological disorder, is primarily characterized by involvement of the fine fibres for temperature and pain perception and also by a variety of autonomic disorders. The great dependence of sensory and sympathetic nerves on NGF, the quantity of results which show alterations in the levels of neurotrophic factors in diabetic neuropathy (DN), and the encouraging experimental and clinical results of using NGF as a new alternative to treatment with DN, were the basic reasons which led us to do this study. CONCLUSIONS: We started by considering neurotrophic factors, especially NGF and its connection with DN disorders and its clinical applications, we made a summary of the main findings in this field to date.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neuropatías Diabéticas
/
Factores de Crecimiento Nervioso
Tipo de estudio:
Clinical_trials
Límite:
Animals
/
Humans
Idioma:
Es
Revista:
Rev Neurol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Cuba
Pais de publicación:
España