Presence of atrial natriuretic peptide in two desert rodents: comparison with rat.
Peptides
; 19(4): 715-26, 1998.
Article
en En
| MEDLINE
| ID: mdl-9622027
Atrial natriuretic peptide (ANP) was characterized and assayed in plasmas, hearts, and brains of two Algerian desert rodents, Psammomys obesus and Meriones libycus along with vasopressin, which was assayed in hypophyses and hypothalami. Using reverse-phase high-performance liquid chromatography and radioimmunoassay, we showed, in plasmas and hearts of both species of desert rats, the presence of peptides similar to rat N- and C-terminal ANP but in lower amounts than in Wistar rats. Conversely, C-terminal ANP was abundantly detected in hypophyses from Meriones libycus rats. As these peptides, through their diuretic and natriuretic activities, are involved in body fluid regulation and electrolyte balance, the reduction of ANP stores in both plasmas and hearts suggests that diuresis and natriuresis are lowered in both species of mammals adapted to arid environments. This could occur because of the vasopressin-mediated adaptation, but also in response to the low ANP involvement in hydro-osmotic regulations, even in Psammomys, which has a dietary salt loading. On the other hand, the higher C-terminal ANP contents in the hypophysis of Meriones than in Psammomys and Wistar rats remain to be understood.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Gerbillinae
/
Factor Natriurético Atrial
/
Aclimatación
Límite:
Animals
País/Región como asunto:
Africa
Idioma:
En
Revista:
Peptides
Año:
1998
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Estados Unidos