Metabolic interrelationships, cardiovascular disease, and sex steroids.
Contraception
; 57(3): 183-7, 1998 Mar.
Article
en En
| MEDLINE
| ID: mdl-9617534
ABSTRACT
PIP: Previous studies of the pharmacodynamics of sex steroids in vivo have tended to focus on single metabolic processes, with scant attention to their integration. This paper reviews the human in vivo research evidence on the effects of diet on metabolism, the central role of insulin in metabolic control, and the interaction between lipid metabolism and hematologic factors. There is a need for more attention to events occurring within vascular tissue itself, especially at the site of atherosclerosis and thrombus formation. Insulin has been proposed as a major physiologic regulator of plasminogen activator inhibitor, and hyperinsulinemia is associated with increased blood coagulability and decreased fibrinolysis. There is a close association between insulin and triglyceride metabolism, and this may affect factor VII activity in blood. Changes in both the quantity and composition of dietary fat influence lipid metabolism as well as blood levels of a number of hematologic factors. Sex steroid-induced changes in aspects of metabolism such as blood lipid concentrations may not be as central to cardiovascular disease risk as originally believed. Changes in carbohydrate metabolism and in hematologic parameters induced by the currently used doses of sex steroids appear to be minor, although more intensive studies are recommended. Evidence suggests that genetic and early life influences are more important to the development of insulin resistance than later acquired causes.
Palabras clave
Arterial Occlusive Diseases; Arteriosclerosis; Atherosclerosis; Biology; Blood Coagulation Effects; Cardiovascular Effects; Contraception; Contraceptive Methods--pharmacodynamics; Contraceptive Methods--side effects; Diet; Diseases; Family Planning; Health; Hematological Effects; Hemic System; Lipid Metabolic Effects; Lipids; Literature Review; Metabolic Effects; Nutrition; Oral Contraceptives, Combined--pharmacodynamics; Oral Contraceptives, Combined--side effects; Oral Contraceptives--pharmacodynamics; Oral Contraceptives--side effects; Physiology; Vascular Diseases
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hormonas Esteroides Gonadales
/
Enfermedades Cardiovasculares
/
Metabolismo
Límite:
Female
/
Humans
Idioma:
En
Revista:
Contraception
Año:
1998
Tipo del documento:
Article
País de afiliación:
Reino Unido
Pais de publicación:
Estados Unidos