Novel cytotoxic diterpenes, excavatolides A-E, isolated from the Formosan gorgonian Briareum excavatum.

Sheu, J H; Sung, P J; Cheng, M C; Liu, H Y; Fang, L S; Duh, C Y; Chiang, M Y

Sheu, J H; Sung, P J; Cheng, M C; Liu, H Y; Fang, L S; Duh, C Y; Chiang, M Y.

Afiliación

Sheu JH; Department of Marine Resources and Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan 804, Republic of China.

J Nat Prod ; 61(5): 602-8, 1998 May.

Article en En | MEDLINE | ID: mdl-9599257

RESUMEN

The chemistry of Briareum excavatum, a Formosan gorgonian coral, was investigated. This study has led to the isolation of five novel marine natural products, excavatolides A-E (1-5), together with brianolide (6). The structures of the above compounds were established by spectral and chemical methods. The relative configuration of excavatolide B (2) was further confirmed by a single-crystal X-ray structure analysis. Cytotoxicity of these compounds toward various cancer cell lines also is described.

Asunto(s)

Antineoplásicos/aislamiento & purificación; Cnidarios/química; Diterpenos/aislamiento & purificación; Animales; Antineoplásicos/química; Antineoplásicos/farmacología; Cristalografía por Rayos X; Diterpenos/química; Diterpenos/farmacología; Ensayos de Selección de Medicamentos Antitumorales; Humanos; Espectroscopía de Resonancia Magnética; Estructura Molecular; Espectrometría de Masa Bombardeada por Átomos Veloces; Células Tumorales Cultivadas

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cnidarios / Diterpenos / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: J Nat Prod Año: 1998 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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