Hypothalamic CART is a new anorectic peptide regulated by leptin.

Kristensen, P; Judge, M E; Thim, L; Ribel, U; Christjansen, K N; Wulff, B S; Clausen, J T; Jensen, P B; Madsen, O D; Vrang, N; Larsen, P J; Hastrup, S

Kristensen, P; Judge, M E; Thim, L; Ribel, U; Christjansen, K N; Wulff, B S; Clausen, J T; Jensen, P B; Madsen, O D; Vrang, N; Larsen, P J; Hastrup, S.

Afiliación

Kristensen P; Health Care Discovery, Novo Nordisk, Bagsvaerd, Denmark. pekr@novo.dk

Nature ; 393(6680): 72-6, 1998 May 07.

Article en En | MEDLINE | ID: mdl-9590691

RESUMEN

The mammalian hypothalamus strongly influences ingestive behaviour through several different signalling molecules and receptor systems. Here we show that CART (cocaine- and amphetamine-regulated transcript), a brain-located peptide, is a satiety factor and is closely associated with the actions of two important regulators of food intake, leptin and neuropeptide Y. Food-deprived animals show a pronounced decrease in expression of CART messenger RNA in the arcuate nucleus. In animal models of obesity with disrupted leptin signalling, CART mRNA is almost absent from the arcuate nucleus. Peripheral administration of leptin to obese mice stimulates CART mRNA expression. When injected intracerebroventricularly into rats, recombinant CART peptide inhibits both normal and starvation-induced feeding, and completely blocks the feeding response induced by neuropeptide Y. An antiserum against CART increases feeding in normal rats, indicating that CART may be an endogenous inhibitor of food intake in normal animals.

Asunto(s)

Anorexia/metabolismo; Hipotálamo/fisiología; Proteínas del Tejido Nervioso/fisiología; Proteínas/fisiología; Animales; Núcleo Arqueado del Hipotálamo/metabolismo; Clonación Molecular; Escherichia coli; Ayuno; Conducta Alimentaria/fisiología; Regulación de la Expresión Génica; Hipotálamo/metabolismo; Técnicas para Inmunoenzimas; Leptina; Ratones; Proteínas del Tejido Nervioso/genética; Proteínas del Tejido Nervioso/metabolismo; Neuropéptido Y/biosíntesis; Neuropéptido Y/fisiología; Obesidad/metabolismo; ARN Mensajero/metabolismo; Ratas; Ratas Wistar; Ratas Zucker; Proteínas Recombinantes de Fusión; Transducción de Señal

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas / Anorexia / Hipotálamo / Proteínas del Tejido Nervioso Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nature Año: 1998 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido

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