Transgenic mice as research tools in neurocarcinogenesis.
J Neurovirol
; 4(2): 159-74, 1998 Apr.
Article
en En
| MEDLINE
| ID: mdl-9584953
Transgenic animal models for neurocarcinogenesis have provided significant insights into the molecular mechanisms underlying carcinogenic processes, including those which affect the nervous system. In view of the very rapid pace of acquisition of knowledge, it is not possible to cover all transgenic mouse models for neural tumors. Instead, this article discusses some of the most important technical innovations for manipulation of the mammalian genome (notably the various methods for targeted genome modifications, as well as the technology for introducing large DNA fragments into the germ line of mice), and presents a selection of the transgenic mouse models which are proving most promising for furthering our understanding of the pathogenetic basis of cancer in the nervous system.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ratones Transgénicos
/
Modelos Animales de Enfermedad
/
Neoplasias del Sistema Nervioso
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Neurovirol
Asunto de la revista:
NEUROLOGIA
/
VIROLOGIA
Año:
1998
Tipo del documento:
Article
País de afiliación:
Suiza
Pais de publicación:
Estados Unidos