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Correlation of prostate specific antigen immunoactivity (IR-PSA) to other prognostic factors in female breast cancer.
Griniatsos, J; Diamantis, E; Gioti, J; Karyda, I; Vassilopoulos, P P; Agnanti, N.
Afiliación
  • Griniatsos J; Saint-Savvas Anticancer Hospital, Athens, Greece.
Anticancer Res ; 18(1B): 683-8, 1998.
Article en En | MEDLINE | ID: mdl-9584052
Recently, using an ultrasensitive time-resolved immuno-fluorometric assay, PSA immunoreactivity (IR-PSA) was found in breast tumor cytosols. We retrospectively studied 219 breast cancer patients, measuring IR-PSA in the tumor cytosols, and classified the breast cancers as either PSA positive or PSA negative based on an IR-PSA cut off level of 1 pg/mg. Multivariated analysis showed that IR-PSA is an independent favourable prognostic indicator for postmenopausal, node positive breast cancer patients. Additionally, IR-PSA correlates with reduced risk of relapse in ER+ve tumors and is negatively correlated with mutated p53, which increases the risk of relapse.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Antígeno Prostático Específico Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Anticancer Res Año: 1998 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Grecia
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Antígeno Prostático Específico Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Anticancer Res Año: 1998 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Grecia