Periodic fluctuations of gut regulatory peptides in phase with the duodenal migrating myoelectric complex in preruminant calves: effect of different sources of dietary protein.
Br J Nutr
; 79(3): 287-96, 1998 Mar.
Article
en En
| MEDLINE
| ID: mdl-9577307
Four preruminant calves with implanted electrodes in the duodenum and a catheter in the external jugular vein were used for investigation of plasma gut regulatory peptide profiles during different phases of migrating myoelectric complex (MMC) in the small intestine. The effects of different dietary proteins on the rhythmic activity of gut peptides and gastrointestinal motility were compared. In particular, the effects of skimmed-milk protein (retaining physiological patterns of abomasal clotting, and abomaso-intestinal digesta flow) v. fish protein (devoid of clotting activity and modifying the digesta flow) were studied. In calves fed on the milk diet, plasma concentrations of pancreatic polypeptide, motilin, secretin, cholecystokinin (CCK) and somatostatin, but not vasoactive intestinal polypeptide or gastrin, fluctuated in phase with the duodenal MMC in the preprandial period. Feeding transiently affected the intestinal MMC and abolished the peptide fluctuations in a specimen-specific manner. In contrast, calves fed on the fish-protein diet showed more profound changes in intestinal MMC. In these animals the MMC-related fluctuations were significant only for plasma CCK. In conclusion, the source of dietary protein has an impact on the physiological endocrine function of the small intestine. Observed fluctuations of plasma gut regulatory peptides seem to be secondary to duodenal motility cycles.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bovinos
/
Proteínas en la Dieta
/
Complejo Mioeléctrico Migratorio
/
Duodeno
/
Hormonas Gastrointestinales
/
Animales Recién Nacidos
Límite:
Animals
Idioma:
En
Revista:
Br J Nutr
Año:
1998
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Reino Unido