Investigation of the potential interaction between terfenadine and tedisamil in human liver microsomes.
Xenobiotica
; 28(3): 219-23, 1998 Mar.
Article
en En
| MEDLINE
| ID: mdl-9574812
1. The potential drug-drug interaction of terfenadine and tedisamil has been investigated. Terfenadine is a widely used antihistamine drug with the potential for QTC prolongation. Tedisamil is a potassium channel blocking agent known to produce bradycardia and prolong the effective refractory period in man. 2. Tedisamil and terfenadine were incubated with human liver microsomes for 30 min at 37 degrees C. No significant inhibition of terfenadine biotransformation was seen with 0.1 or 10 microM tedisamil as the formation of the terfenadine alcohol and acid metabolites were unaffected. 3. Based on the in vitro results it is suggested that tedisamil will not interact pharmacokinetically with terfenadine as it does not impair metabolism of terfenadine.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Microsomas Hepáticos
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Cardiotónicos
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Terfenadina
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Compuestos Bicíclicos Heterocíclicos con Puentes
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Ciclopropanos
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Antagonistas de los Receptores Histamínicos H1
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Xenobiotica
Año:
1998
Tipo del documento:
Article
Pais de publicación:
Reino Unido