Lipoprotein(a) inhibits lipopolysaccharide-induced tumor necrosis factor alpha production by human mononuclear cells.

Netea, M G; de Bont, N; Demacker, P N; Kullberg, B J; Jacobs, L E; Verver-Jansen, T J; Stalenhoef, A F; Van der Meer, J W

Netea, M G; de Bont, N; Demacker, P N; Kullberg, B J; Jacobs, L E; Verver-Jansen, T J; Stalenhoef, A F; Van der Meer, J W.

Afiliación

Netea MG; Department of Medicine, University Hospital Nijmegen, The Netherlands.

Infect Immun ; 66(5): 2365-7, 1998 May.

Article en En | MEDLINE | ID: mdl-9573133

RESUMEN

Lipoproteins can bind lipopolysaccharide (LPS) and decrease LPS-stimulated cytokine production. Lipoprotein(a) [Lp(a)] was as potent as low-density lipoproteins (LDL) in inhibiting LPS-stimulated tumor necrosis factor synthesis by human mononuclear cells. The kinetics of LPS inhibition by Lp(a) was similar to that of LDL. This suggests that circulating Lp(a) may be an important factor determining the amplitude of the response to LPS in humans.

Asunto(s)

Leucocitos Mononucleares/efectos de los fármacos; Lipopolisacáridos/antagonistas & inhibidores; Lipoproteína(a)/farmacología; Factor de Necrosis Tumoral alfa/biosíntesis; Humanos; Leucocitos Mononucleares/metabolismo; Lipoproteínas LDL/farmacología

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucocitos Mononucleares / Lipopolisacáridos / Factor de Necrosis Tumoral alfa / Lipoproteína(a) Límite: Humans Idioma: En Revista: Infect Immun Año: 1998 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos

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