Gabapentin does not interact with a contraceptive regimen of norethindrone acetate and ethinyl estradiol.
Neurology
; 50(4): 1146-8, 1998 Apr.
Article
en En
| MEDLINE
| ID: mdl-9566412
ABSTRACT
PIP: Anticonvulsants that induce hepatic metabolism increase the clearance of synthetic estrogens and progestogens used in oral contraceptives (OCs), thereby potentiating contraceptive failure. In contrast, the anticonvulsant drug gabapentin is not metabolized in humans and has little liability for metabolic-based drug interactions. The present study sought to confirm whether concurrent administration of gabapentin would alter the pharmacokinetics of norethindrone acetate (2.5 mg) and ethinyl estradiol (50 mcg) in healthy US women. A total of 13 women were enrolled for three menstrual cycles each. Pharmacokinetic values did not change appreciably as a result of the addition of gabapentin. The rate and extent of absorption of both hormones were unaffected by the anticonvulsant. Gabapentin plasma concentration time profiles and pharmacokinetic values from this study were similar to historical values after administration of gabapentin alone. The observed lack of interaction between gabapentin and norethindrone acetate or ethinyl estradiol is consistent with the fact that gabapentin is not metabolized, is not an inducer or inhibitor of hepatic drug metabolizing enzymes, is absorbed via a specific transport system for amino acids, and is not bound to plasma proteins. Anticonvulsant drugs that do not interact with OCs should be considered for the treatment of epileptic women of childbearing age who are using this method of fertility control.
Palabras clave
Americas; Biology; Clinical Research; Contraception; Contraceptive Agents, Estrogen--pharmacodynamics; Contraceptive Agents, Female--pharmacodynamics; Contraceptive Agents, Progestin--pharmacodynamics; Contraceptive Agents--pharmacodynamics; Contraceptive Methods--pharmacodynamics; Developed Countries; Drug Interactions; Drugs; Ethinyl Estradiol--pharmacodynamics; Family Planning; Hepatic Effects; Norethindrone Acetate--pharmacodynamics; Norethindrone--pharmacodynamics; North America; Northern America; Oral Contraceptives, Combined--pharmacodynamics; Oral Contraceptives--pharmacodynamics; Physiology; Research Methodology; Research Report; Treatment; United States
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Anticonceptivos Sintéticos Orales
/
Ácidos Ciclohexanocarboxílicos
/
Congéneres del Estradiol
/
Etinilestradiol
/
Ácido gamma-Aminobutírico
/
Aminas
/
Acetatos
/
Anticonvulsivantes
/
Noretindrona
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Neurology
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos