IL-12 prevents neonatal induction of transplantation tolerance in mice.
Eur J Immunol
; 28(4): 1426-30, 1998 Apr.
Article
en En
| MEDLINE
| ID: mdl-9565383
We investigated the effect of IL-12 on the induction of transplantation tolerance by neonatal injection of allogenic cells. We first observed that injection of newborn BALB/c mice with IL-12 and (A/J x BALB/c)F1 spleen cells prevented the Th2 alloimmune response induced by neonatal inoculation of F1 cells alone and allowed the differentiation of T cells secreting high amounts of IL-2 and IFN-gamma in mixed lymphocyte cultures with donor-type stimulators. Furthermore, IL-12 administration resulted in the emergence of anti-donor cytotoxic T lymphocyte responses although at lower levels than in control uninjected mice. In parallel, we found that mice injected at birth with IL-12 and F1 cells did not develop chimerism and were able to reject a donor-type skin graft as efficiently as control mice. We conclude that IL-12 inhibits the Th2 polarization of the newborn response to alloantigens and prevents thereby the establishment of transplantation tolerance.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trasplante de Células
/
Células Th2
/
Interleucina-12
/
Supervivencia de Injerto
/
Tolerancia Inmunológica
Límite:
Animals
Idioma:
En
Revista:
Eur J Immunol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Bélgica
Pais de publicación:
Alemania