T-cell receptor-gamma rearrangement and c-myb methylation in MNNG-exposed Bloom syndrome B-lymphoblastoid cells.
Cancer Lett
; 126(1): 1-6, 1998 Apr 10.
Article
en En
| MEDLINE
| ID: mdl-9563641
The MNNG-exposed Bloom syndrome (BS) B-lymphoblastoid cell population (BS-MNNG), when analyzed for aberrant genetic variations, showed an illegitimate rearrangement at the TCR-gamma gene and hypermethylation at the c-myb protooncogene. The TCR-gamma rearrangement involved a Vgamma9 segment corresponding to a 4 kb band detected with a Jgamma-specific probe in HindIII-digested DNA samples from BS-MNNG cells only. These variations were not shown by unexposed BS cells or both MNNG-exposed and unexposed normal (GA3) B-lymphoblastoid cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oncogenes
/
Síndrome de Bloom
/
Reordenamiento Génico de la Cadena gamma de los Receptores de Antígenos de los Linfocitos T
Límite:
Humans
Idioma:
En
Revista:
Cancer Lett
Año:
1998
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
Irlanda