Cerebrospinal fluid carnitine levels in patients with Alzheimer's disease.
J Neurol Sci
; 155(2): 192-5, 1998 Mar 05.
Article
en En
| MEDLINE
| ID: mdl-9562266
We assessed free carnitine (FC) and acylcarnitine esters (AC) in both cerebrospinal fluid (CSF) and plasma from 24 patients with diagnostic criteria for Alzheimer's disease (AD), and from 28 healthy matched-controls. We found no significant correlation between FC and AC levels in CSF. FC and AC levels in CSF did not differ significantly between AD patients and controls, but plasma FC levels were significantly lower in AD patients. CSF and plasma FC and AC levels did not correlate with age, age at onset of AD, duration of AD, and scores of the Minimental State Examination of Folstein. Although these results suggest that CSF carnitine levels are apparently unrelated with the risk for AD, the trend of the FC/AC ratio to be higher in AD patients might suggest the possibility of a lower carnitine acetyltransferase activity in AD, as previously reported in some brain areas.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carnitina
/
Enfermedad de Alzheimer
Límite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Neurol Sci
Año:
1998
Tipo del documento:
Article
País de afiliación:
España
Pais de publicación:
Países Bajos