Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development.
Curr Opin Cell Biol
; 10(2): 205-19, 1998 Apr.
Article
en En
| MEDLINE
| ID: mdl-9561845
The c-Jun amino-terminal kinase (JNK) group of MAP kinases has been identified in mammals and insects. JNK is activated by exposure of cells to cytokines or environmental stress, indicating that this signaling pathway may contribute to inflammatory responses. Genetic and biochemical studies demonstrate that this signaling pathway also regulates cellular proliferation, apoptosis, and tissue morphogenesis. A functional role for JNK is therefore established in both the cellular response to stress and in many normal physiological processes.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Proteínas Quinasas Dependientes de Calcio-Calmodulina
/
Proteínas Quinasas Activadas por Mitógenos
/
Inflamación
/
Morfogénesis
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Cell Biol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido