Immunological status in tuberous sclerosis.
Dev Med Child Neurol
; 18(4): 503-11, 1976 Aug.
Article
en En
| MEDLINE
| ID: mdl-955313
Cellular and humoral immunity, and lymphoid organ pathology, have been investigated in 10 institutionalized patients with tuberous sclerosis and 10 institutionalized matched controls without the disease. Type and incidence of infections and tumours were reviewed for each group, as was current medication. Elevated serum IgM levels were found in the patients with tuberous sclerosis, but no immunological deficiency of either cellular of humoral immunity was found, nor was there a difference in infection between the groups. Only patients with tuberous sclerosis had evidence of neoplasia. No morphological or histological abnormalities of lymph nodes, spleen or thymus were present. Explanations for the difference between tuberous sclerosis and ataxia telangiectasia are discussed, together with the effect of immuno-surveillance on the development of malignancy.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Esclerosis Tuberosa
Límite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Dev Med Child Neurol
Año:
1976
Tipo del documento:
Article
Pais de publicación:
Reino Unido