Prevalence of allergy in children in relation to prior BCG vaccination and infection with atypical mycobacteria.
Allergy
; 53(3): 249-54, 1998 Mar.
Article
en En
| MEDLINE
| ID: mdl-9542604
By influence on the Th1/Th2 cell balance, infectious agents may affect the development of atopic allergy. In this study, we investigated whether previous BCG vaccination or infection with atypical mycobacteria might be related to the development of atopic disease. The study, which involved skin testing with mycobacteria and answers to a questionnaire for more than 6000 children in Sweden, revealed a low prevalence of allergy among BCG-vaccinated children who were immigrants or adopted from other countries. Vaccinated children born in Sweden, however, did not have significantly lower allergy prevalence than age-matched, unvaccinated children. Furthermore, the overall frequencies of skin-test reactivity to the atypical mycobacteria M. avium and M. scrofulaceum were higher rather than lower in allergic than in nonallergic children. By contrast, there was a tendency toward a lower frequency of more strongly positive skin reactions (> or = 10 mm) to mycobacteria in allergic than in nonallergic children. These findings do not support the hypothesis that early mycobacterial infections have a suppressive effect on the development of atopic disease. Earlier findings of an apparent association between atopy and lack of previous mycobacterial infection may possibly be explained by a relatively decreased ability of atopic patients to mount strong Th1 cell-mediated immune responses.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pruebas Cutáneas
/
Vacuna BCG
/
Hipersensibilidad Inmediata
/
Infecciones por Mycobacterium no Tuberculosas
Tipo de estudio:
Prevalence_studies
/
Risk_factors_studies
Límite:
Child
/
Child, preschool
/
Humans
Idioma:
En
Revista:
Allergy
Año:
1998
Tipo del documento:
Article
País de afiliación:
Suecia
Pais de publicación:
Dinamarca