Evaluation of a filling system for binary pediatric solutions.
Pharm World Sci
; 20(1): 32-7, 1998 Feb.
Article
en En
| MEDLINE
| ID: mdl-9536469
The aim of this study was to assess the use of an automatic filling system (Siframix M31 and M32 system) to prepare pediatric parenteral nutrition. Volumetric accuracy was measured for each siframix system loads cells (< 5% for 5 ml with the Siframix M32 and < 5% for 9 ml with the Siframix M31) with sterile water for injection. The minimal 20 ml of flushing sterile water of the common tubulure of the Siframix M32 (p = 0.211 for 20 ml and p = 0.75 for 500 ml), the use of viscous solutions (70% dextrose) on the Siframix M31 (p = 0.28 for 20 ml and p = 0.12 for 500 ml) and the use of a special tubulure for using E.V.A. Luer-lock bags (p = 0.89 for 20 ml and p = 0.103 for 500 ml) do not modify the accuracy. Changing bags or bottles during the filling operation modify the accuracy (p = 0.004 for 20 ml and p = 0.009 for 500 ml). A flushing operation is necessary to lower the risk of electrolytic pollution for the filling of little bags. The filling speed for each module was also measured (the maximal filling speed was five liters per minute). The Siframix system allows one to prepare pediatric parenteral nutrition bags when volumes are above 4 ml and with adapted source solutions in terms of concentration and conditioning volumes.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nutrición Parenteral
/
Soluciones Farmacéuticas
Límite:
Child
/
Humans
Idioma:
En
Revista:
Pharm World Sci
Asunto de la revista:
FARMACIA
/
TERAPIA POR MEDICAMENTOS
Año:
1998
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Alemania